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Comparison Between various Histological zones of Hepatic Acinus

Parameter

zone l

Zone II

zone III

Region of hepatic acinus

Central area (between two portal triads)

Intermediate area

Peripheral area (nearer to central vein

Hepatocytes tultrastructure)

Gluconeogenesis

Glycolysis

Lipid metabolism

Smooth endoplasmic reticulum

Rough endoplasmic reticulum

Mitochondria

Glycogen

Maximum

Minimum

Minimum

Sparse

More

Few & elongated More abundant

Optimum Optimum Optimum Optimum Optimum Optimum Optimum

Minimum Maximum Minimum well developed Sparse

Numerous & quite

small

Sparse

Nutritive and oxygenated blood supply

Maximum

Optimum

Minimum

vulnerability to hypoxia

Minimum

Optimum

Maximum

vulnerability to metabolic changes

Maximum

Optimum

Minimum

vulnerability to damage by toxins

Maximum

Optimum

Minimum

vulnerability to necrosis by yellow fever

Minimum

Maximum

Minimum

vulnerability to drugs, chemical toxicity and right heart failure

Minimum

Optimum

Maximum

Comparison Between various Histological zones of Hepatic Acinus

 

 

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