Classification of PURGATIVES

Classification of PURGATIVES

Pugatives can be classified on a number of bases
1. INTENSITY OF ACTION
a) LAXATIVES
b) PURGATIVES
c) DRASTICS
2. SITE OF ACTION
a) SMALL GUT
Castor oil . irritant resins
b) LARGE GUT
Anthracene purgatives , bisacodyl suppositories,phenophthalene
c) SMALL AND LARGE GUT
Saline purgatives and lubricants
3. MECHANISM OF ACTION
a) STIMULANT PURGATIVES
These drugs promote the peristaltic movements of drugs by causing irritation.
i) DRUG WHICH ACT ON LARGE INTESTINE
a) BISACODYL
b) ANTHRACENE DERIVATIVES
Aloe , senna , cascaia sagarada
c) DIPHENYLMETHANE DERIVATIVES
ii) DRUGS ACTING ON SMALL INTESTINE
a) OILS
Castor oil
b) RESINS
Podophyllum
b) BULK FORMING PURGATIVES
i) COLLOIDAL PURGATIVES
a) NATURAL PLANT PRODUCTS
Psyllium,methylcellulose,bran,ispaghula,agar-agar
b) SYNTHETIC FIBERS
Polycarbophil
ii) OSMOTIC PURGATIVES
a) NON-ABSORBABLE SUGARS
Lactulose,sorbital
b) NON-ABSORBABLE SALTS
Magnesium oxide,magnesium citrate,sodium phosphate
c) BALANCED POLYETHYLENE GLYCOL
c) STOOL SURFACTANT AGENTS (SOFTNERS)
i) LUBRICANTS
Liquid parrafin,mineral oil,bland vegetable oils
ii) DIOCTYL SODIUM SULPHOSUCCINATE
iii) GLYCERIN SUPPOSITORY
d)MISCELLANEOUS DRUGS
i) SEROTONIN 5-HT4-RECEPTOR AGONISTS
ii) PARASYMPATHOMIMETICS
Neostigmine , distigmine