fat soluble vitamin doses in neonatal cholestasis

 Fat-Soluble Vitamin Supplementation in the Cholestatic Infant
Vitamin Laboratory Sign of Deficiency Clinical Sign of Deficiency Treatment/Prevention
Vitamin A Retinol: retinol-binding
protein <0.8 mol/mol
Xerophthalmia, keratomalacia Vitamin A: 3,000–10,000 U/d
Vitamin D 25-Hydroxyvitamin
D <14 ng/mL [ deficiency;
<30 ng/mL [ insufficiency
Rickets, osteomalacia Cholecalciferol: 800–5,000 IU/d;
1,25 OH2 cholecalciferol:
0.05–0.2 mg/kg per d
Vitamin K Prolonged prothrombin time,
elevated protein in
vitamin K absence
Coagulopathy Phytonadione: 2.5–5 mg twice
a week to every day
Vitamin E Vitamin E: total serum
lipid ratio <0.6 mg/g
Neurologic changes,
hemolysis
TPGS: 15–25 U/kg per d; D-a
tocopherol: up to 100 U/kg
per d
TPGS¼D-a-tocopheryl polyethylene glycol 1,000 succinate.