Live Offspring after Testis Tissue Transplantation

Live Offspring after Testis Tissue Transplantation
NEJM
October,2019

Kids treated for malignancies such as leukemia often lose their fertility as adverse response to chemo/radiotherapy.

In Post pubertal patients,saving sperms is one method to secure reproductive potential.

However,this can't be done in prepubertal patients.

In prepubertal monkeys, testicular tissues were biopsied and frozen/preserved in liquid nitrogen(cryopreservation). The monkeys were castrated. As they reached pubertal age,testicular tissue was grafted in scrotum. This tissue grew in size and viable spermatoza were produced. Using these sperms in vitro fertilization was done,embryo was transferred to healthy female monkey which resulted in healthy baby being born.

Fluoroquinolones could cause arrhythmias

Fluoroquinolones are associated with increased risk of sudden cardiac death, via the mechanism of cardiac arrhythmias due to QT prolongation.

This study published in July, includes 7657 cases of serious arrhythmia out of 2million total participants. Out of 7657 cases it was found that those patient who were advised fluroquinolones had 50percent more odds to have deadly arrhythmia irrespective of duration of onset of arrhthymia (7 days to 90 days).

Published in Resuscitation by Elsevier.

https://www.resuscitationjournal.com/article/S0300-9572(18)30736-6/fulltext

*FDA* has warned previously that fluoroqyinolones

Ciprofloxacin/Levofloxacin/Moxifloxacin etc may cause agitation/delirium/memory issues/ or even hypoglycemic comma.

So if we have a kid/adult patient having such symptoms we should keep in mind history of  ciprofloxacin prescription specifically.

Lastly FDA had also issued a warning last year that these drugs can cause aortic dissection.

I couldn't assess here if these effects are dose dependant or just related to chemical nature of these drugs.