Wednesday, June 21, 2017

Classification Of Anticoagulant Drugs

Classification Of Anticoagulant Drugs

Vitamin K Antagonists as Anticoagulant Drugs
(inhibit II, VII, IX, X) coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol (Dicumarol) • Ethyl biscoumacetate • Phenprocoumon • Warfarin
1,3-Indandiones: Clorindione • Diphenadione • Phenindione
Factor Xa Inhibitors as Anticoagulant Drugs:
(with some II inhibition) Heparin group/
glycosaminoglycans/
(bind antithrombin) low molecular weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
oligosaccharides (Fondaparinux, Idraparinux)
heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)
Direct Xa Inhibitors as Anticoagulant Drugs:
xabans (Apixaban, Otamixaban, Rivaroxaban)
Direct Thrombin (II) Inhibitors as Anticoagulant Drugs:
Bivalent:
Hirudin (Bivalirudin, Lepirudin, Desirudin)
Univalent:
Argatroban • Dabigatran • Melagatran • Ximelagatran
Other Anticoagulant Drugs:
Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

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