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The ultrastructure of hepatocytes

The ultrastructure of hepatocytes differs In the three zones. As gluconeogenesis occurs primarily in zone I; so SER is sparse, mitochondria are elongated and glycogen is more abundant.

As glycolysis and lipid metabolism is frequent in zone III, so SER is well developed here and the mitochondria are numerous and quite small. The glycogen is sparse.

The hepatocytes of zone II show intermediate features.

 

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