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Multiple Myeloma ..points of interest.

Multiple myeloma points of interest :

• Bone punched out lesion...> due to osteoclasts activating factor, and

osteoblasts differentiation inhibitor.
• When light chains get converted into amyloid, they cause nephrotic

syndrome.
• Proteinaceous tubular casts in urine (light chains), tubular basement

membrane calcinosis, and acute renal failure.
• Normocytic anemia, rouleaux formation, quantitative platelets defect.
• Most common cause of death is infection (St.pneumonia, and H.influenza)

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