Multiple myeloma points of interest :
• Bone punched out lesion...> due to osteoclasts activating factor, and
osteoblasts differentiation inhibitor.
• When light chains get converted into amyloid, they cause nephrotic
• Proteinaceous tubular casts in urine (light chains), tubular basement
membrane calcinosis, and acute renal failure.
• Normocytic anemia, rouleaux formation, quantitative platelets defect.
• Most common cause of death is infection (St.pneumonia, and H.influenza)