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Classification of Antifungal drugs

Classification of Antifungal drugs

ANTIFUNGAL DRUGS
CLASSIFICATION:-
· ACCORDING TO CHEMICAL STRUCTURE:
1) Antifungal antibiotics:-
a) Polyenes:Amphotericin B, Nystatin, Natamycin
b) Heterocyclic Benzofurans: Griseofulvin
2) Synthetic Antifungal drugs:-
i) Azoles:
(a) Imidozole derivatives: Clotrimazole, Econazole, Miconazole, Ketoconazole, Oxiconazole
(b) Triazole derivatives: Fluconazole, Intraconazole
ii) Allylamines: Terbinafine, Naftifine
iii) Thiocarbamate;Tolnaftate
iv) Derivatives of Unecyclenic acid: Ointment”Zincudin” & Undecin
v) Pyrimidine Antagonists: Flucytosine
vi) Echinocandin: Caspofungin, Micafungin, Anidulafungin
vii) Antifungal drugs with other chemical structure:
(a) Degudinium chloride
(b) Iodine Drugs: KI
(c) Drugs of salicyclic acid
· ACCORDING TO MODE OF ACTION:-
1) Alter cell permeability: Azoles, Polyenes, Terbinafine
2) Disrupt microtubule function: Griseofulvin
3) Ergosterol binding: Amphotericin
4) DNA-RNA inhibitors: Flucytosine
5) Ergosterol synthesis inhibitors/P450 inhibitors: Ketoconazole, Itraconazole, Fluconazole, Voriconazole
6) B(1-3) glucan inhibitors: Caspofungin, Micafungin, Anidulafungin
· ACCORDING TO SITE OF ACTION:-
1) Systemic Antifungal Drugs
i) For Systemic Mycoses: Amphotericin B, Flucytosine, Azoles, Echinocandins
ii) For Mucocutaneous Mycoses: Griseofulvin, Terbinafine
2) Topical Antifungal Drugs: Nystatin, Topical Azoles, Topical Allylamine

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