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Classification of sulfonamides

Classification of sulfonamides

Chemical classification of sulfonamides

(1) N1 substituted sulfonamides
Sulfapyridine
Sulfadiazine
(2) N4 substituted sulfonamides: (Prodrugs which require change to N4 unsubstituted form to show activity)
Sulfasilazine
CLassification of sulfonamides According to Pharmacokinetics
1. Orally absorbable sulfonamides
(a). Short acting sulfonamides:
Sulfisoxazole
Sulfamethoxazole (SMX)
(b). Intermediate acting sulfonamides:
Sulfadiazine
(c). Long acting sulfonamides
Sulfadoxine
Sulfadimethoxine
(2). orally non absorbable sulfonamides
Sulfasalazine
(3). Topical sulfonamides:
Sodium sulfacetamide
Mafenide acetate
Silver sulphadiazine
Classification of sulfonamides according to site of action:
(a) Kidney (diuretics) sulfonamides:
Acetazolamide
Bumetanide
Clopamide
Furosemide
Indapamide
Metolazone
Xipamide
(b) Ophthalmologic sulfonamides:
Dichlorophenamide
Dorzolamide
(c) Dermatological sulfonamides:
Silver sulfadiazine
Mafenide
Therapeutic classification of sulfonamides
(1). UTI sulfonamides:
Sulfisoxazole
Sulfamethoxazole
(2). Acute toxoplasmosis sulfonamides:
Sulfadiazine+pyrimethamine(dihydrofolate reductase inhibitor)
(3). Malaria sulfonamides
Sulfadioxine+pyrimethamine (fansidar)
(4). Ulcerative colitis, enteritis, inflammatory bowel disease sulfonamides:
Sulfasilazine
(5). Bacterial conjunctivitis sulfonamides:
Sodium sulfacetamide
(6). Burn infections sulfonamides:
Silver sulfadiazine

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