Live Offspring after Testis Tissue Transplantation
NEJM
October,2019
Kids treated for malignancies such as leukemia often lose their fertility as adverse response to chemo/radiotherapy.
In Post pubertal patients,saving sperms is one method to secure reproductive potential.
However,this can't be done in prepubertal patients.
In prepubertal monkeys, testicular tissues were biopsied and frozen/preserved in liquid nitrogen(cryopreservation). The monkeys were castrated. As they reached pubertal age,testicular tissue was grafted in scrotum. This tissue grew in size and viable spermatoza were produced. Using these sperms in vitro fertilization was done,embryo was transferred to healthy female monkey which resulted in healthy baby being born.
NEJM
October,2019
Kids treated for malignancies such as leukemia often lose their fertility as adverse response to chemo/radiotherapy.
In Post pubertal patients,saving sperms is one method to secure reproductive potential.
However,this can't be done in prepubertal patients.
In prepubertal monkeys, testicular tissues were biopsied and frozen/preserved in liquid nitrogen(cryopreservation). The monkeys were castrated. As they reached pubertal age,testicular tissue was grafted in scrotum. This tissue grew in size and viable spermatoza were produced. Using these sperms in vitro fertilization was done,embryo was transferred to healthy female monkey which resulted in healthy baby being born.
No comments:
Post a Comment