Wednesday, June 21, 2017

CHEMICAL CLASSIFICATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ( NSAIDs ) CLASSIFICATION OF NSAIDS in pharmacology

CHEMICAL CLASSIFICATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ( NSAIDs )
NSAIDS classification is as follows :
CHEMICAL CLASSIFICATION of NSAIDS
A: SALICYLATES
Acetyl salicylic acid (aspirin), sodium salicylate, Mg salicylate, choline salicylate, Na thio salicylate, salicyl salicylate
B: PROPIONIC ACID DERIVATIVES
Ibuprofen, ketoprofen, naproxen, oxaprozin, flurbiprofen
C:INDOLE ACETIC ACID
Indomethacin, sulindac,
D: SUBSTITUTED ANTHRANILIC ACIDS (Rarely used)
Mefenamic acid, meclofenamate Na
E: PYRROLE ALKANOIC ACID (Rarely used)
Tolmetin
F: OXICAMS
Piroxicam, meloxicam
G: DIFLUOROPHENYL DERIVATIVES
Diflunisal
H: PHENYL ACETIC ACID
Diclofenac
I:ACETIC ACID DERIVATIVES
Etodolac
J: NAPHTHYL ACETIC ACID PRODRUGS
Nabumetonre
K: PARA-AMINO PHENOL DERIVATIVES
Acetaminophen

NSAIDS Classification ACCORDING TO MECHANISM OF ACTION
A:NON-SELECTIVE COX INHIBITORS
Diclofenac, etodolac, indomethacin, ketoprofen, ketorolac, nabumetone, naproxen, oxaprozin, ibuprofen, flurbiprofen, diflunisol , piroxicam, sulindac, (tenoxicam, tiattrofin, tolmetin are rarely used and not available in USA)
B: DRUGS MORE EFFECTIVE INHIBITORS OF COX-1
Aspirin, indomethacin, piroxicam, sulindac
C: COX-2 SELECTIVE INHIBITORS
Celecoxip, etoricoxib, meloxicam

THERAPEUTIC CLASSIFICATION OF NSAIDS
A: ANALGESICS
Aspirin, paracetamol
B: ANTI-INFLAMMATORY
Indomethacin, naproxen, ibuorofen
C: ANTI-COAGULANTS
Aspirin
D: ANTI-PYRETICS
Aspirin, paracetamol, indomethacin, celecoxicv, ibuprofen
E: INFLAMMATORY BOWEL DISEASE
Sulfasalazine, infiximab
F: ANTI-CANCER DRUGS
Methotraxate
G: ANTI-MALARIAL
Chloroquine, hydroxychloroquine
H: TISSUE TRANSPLANTATION
Cyclosporine
I: CHELATING AGENTS IN WILSON’S DISEASE
Penicillamine
J: ANTI-GOUT DRUGS
Indomethacin, ibuprofen

W.H.O CLASSIFICATION OF NSAIDS
A: DRUGS WITH WEAK ANTI-INFLAMMATORY EFFECT
Acetaminophen
B: DRUGS WITH MILD TO MODERATE ANTI-INFLAMMATORY EFFECT
Propionic acid derivatives, anthranilic acid derivatives
C: DRUGS WITH MARKED ANTI-INFLAMMATORY EFFECTS
Salicylates, acetic acid derivatives, oxicams, diclofenac, etodolac



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