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Classification of Parasympatholytics

Classification of Parasympatholytics

CHOLINOCEPTOR ANTAGONISTS
1. MUSCARINIC ANTAGONISTS
2. NICOTINIC ANTAGONISTS
MUSCARINIC ANTAGONISTS
1) ON THE BASIS OF CHEMICAL STRUCTURE

a. NATURAL BELLADONA COMPOUNDS
· Atropine(hyoscyamine)
· Hyoscine(scopolamine)
b. SEMISYNTHETIC AND SYNTHETIC SUBSTITUTES
Ø TERTIARY AMINES
· Dicyclomine
· Tropicamide
Ø QUATERNARY AMMONIUM COMPOUNDS
· Ipratropium
· Propantheline
2) ON THE BASIS OF SELECTIVITY

a. NON SELECTIVE
· Ipratropium
· Tropicamide
b. M1 SELECTIVE
· Pirenzipine
· Dicyclomine

c. M2 SELECTIVE
· Gallamine
· Methoctramine
d. MSELECTIVE
· Darifenacin
· Toltorodine
NICOTINIC ANTAGONISTS
1. GANGLION BLOCKERS
2. NEURO MUSCULAR BLOCKERS
GANGLION BLOCKERS
ON THE BASIS OF CHEMICAL STRUCTURE
a. SECONDARY AMINES
· Mecamylamine
b. TERTIARY AMINES
· Pempidine
c. QUATERNARY AMMONIUM COMPOUNDS
· Hexamethonium
· Pentamethonium
d. SULPHONIUM COMPOUNDS
· Trimetaphan
NEUROMUSCULAR BLOCKERS
1. NON-DEPOLARIZING AGENTS
2. DEPOLARIZING AGENTS
NON-DEPOLARIZING AGENTS
1) ON THE BASIS OF CHEMICAL STRUCTURE

a. STEROID DERIVATIVES
· Pancuronium
· Vecuronium
b. ISOQUINOLINE DERIVATIVES
· Tubocurarine
· Atracurium
c. OTHERS
· Gallamine
2) ON THE BASIS OF DURATION OF ACTIION
a. LONG ACTING
· Tubocurarine
· Pancuronium
b. INTERMEDIATE ACTING
· Atracurium
· Vecuronium
c. SHORT ACTING
· Mivacurium
· Rapacuronium
DEPOLARIZING AGENTS
· Suxamethonium
· Decamethonium

THERAPEUTIC CLASSIFICATION OF Parasympatholytics
1) ANTISPASMODICS
· Atropine
· Hyoscine
2) MYDRIATICS
· Atropine
· Tropicamide
· Cyclopentolate
3) ANTI-PARKINSONIAN
· Benzotropine
· Procyclidine
4) ANTI ASTHMATICS
· Ipratropium
· Tiotropium
5) PRE- ANAESTHETICS
· Atropine
· Hyoscine
6) DRUGS USED IN PEPTIC ULCER
· Pirenzipine
· Terenzipine
7) DRUGS USED IN URINARY DISORDERS
· Oxybutynin
· Tolterodine
8) ANTI-HYPERTENSIVES
· Trimetaphan
9) DRGS USED FOR SURGICAL RELAXATION
· Rapacuronium
· Tubocurarine

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