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CLASSIFICATION OF anti-parkinsonism drugs

CLASSIFICATION OF
anti-parkinsonism
drugs


ON THE BASIS OF CHEMICAL PROPERTIES:

1.AMINO ACID PRECURSOR OF DOPAMINE
·    Levodopa
2.ANTIVIRAL
·    Amantadine
3.ERGOT DERIVATIVE
·    Bromocriptine
·    Lysuride
·    Pergolide
·    Carbergoline
·    Quinagolide
·    Mesulergine
4.MORPHINE DERIVATIVE
·    Apomorphine
5.NON ERGOT DERIVATIVES
·    Pramipexole
·    Ropinirole
·    Rotigotine
6.ENZYME INHIBITORS
·    Selegiline (MAO-B inhibitor)
·    Carbidopa (Dopamine Decarboxylase inhibitor)
·    Benserazide (Dopamine Decarboxylase inhibitor)
7.PLACEBO
·    IPX066

8.FATTY ACID
·    Omega 3
Omega 3 in diet protects brain cells by preventing misfolding of a protein resulting from a gene mutation in neurodegenerative diseases like Parkinson’s and Huntington’s.
ON THE BASIS OF MECHANISM OF ACTION

1.SYNTHESIS OF DOPAMINE
·    Levodopa
2.STIMULATION OF DOPAMINE RECEPTORS
·    Bromocriptine
·    Lysuride
·    Pergolide
·    Carbergoline
·    Quinagolide
·    Apomorphine
·    Rotigotine
·    Ropinirole
·    Pramipexole
3.RELEASE OF DOPAMINE FROM INTACT DOPAMINERGIC TERMINALS
·    Amantadine
4.BLOCKING EXCITATORY CHOLINERGIC ACTIVITY
ANTICHOLINERGICS
·    Diphenhydramine
·    Trihexyphenidyl
·    Benztropine
·    Biperiden
·    Procyclidine
·    Orphenadrine
ANTICHOLINERGICS/ANTISPASMODICS
·    Scopolamine
·    Dicyclomine
5.RETARDING BREAKDOWN OF DOPAMINE
·    Selegiline
·    Rosagiline
·    Tranylcyproxime
·    Phenelzine
·    Isocarboxazid
6.PREVENTING METHYLATION OF LEVODOPA
·    Entacapone
·    Tolcapone
7.PREVENTING BREAKDOWN OF LEVODOPA IN THE PERIPHERAL TISSUES
·    Carbidopa
·    Benserazide
8.DELAYING RE-UPTAKE OF DOPAMINE
·    Amantadine
ON THE BASIS OF THE DOPAMINE RECEPTORS EFFECTED

1.D2
·    Bromocriptine
·    Lysuride
·    Carbergoline
·    Quinagolide
·    Ropinirole
2.D1 AND D2
·    Pergolide
·    Apomorphine
3.D3
·    Pramipexole
ON THE BASIS OF SITE OF ACTION

1.CENTRAL
·    Levodopa
·    Selegiline
·    Apomorphine
·    Trihexyphenidyl
2.PERIPHERAL
·    Carbidopa
·    Entacapone
3.CENTRAL AND PERIPHERAL
·    Amantadine
·    Bromocriptine
·    Tolcapone
ON THE BASIS OF ROUTE OF ADMINISTRATION
1.ORAL
·    Levodopa
·    Carbidopa
·    Amantadine
·    Bromocriptine
·    Trihexyphenidyl
·    Selegiline
·    Procyclidine
·    Orphenadrine
2.SUBCUTANEOUS INJECTION
·    Apomorphine
·    Apomorphine accompanied by anti emetic e.g. Domperidone
3.ORAL+INJECTION
·    Benztropine
·    Biperiden
·    Diphenhydramine
ON THE BASIS OF THERAPEUTIC USES

1.RIGIDITY
·    Levodopa
·    Carbidopa
·    Anticholinergic drugs
-Diphenhydramine
-Benztropine
-Procyclidine
2.BRADYKINESIA
·    Carbidopa
·    Levodopa
·    Benserazide
·    Co-reldopa(Levodopa+Carbidopa)
·    Co-beneldopa(Levodopa+Benserazide)
3.TREMORS
·    Diphenhydramine
·    Orphenadrine
·    Biperiden
·    Benztropine
·    Amantadine
4.END-OF-DOSE AKINESIA
·    Bromocriptine
·    Selegiline
·    Levodopa+Selegiline
·    Rosagiline

5.ON-OFF PHENOMENON
·    Dopamine Agonists
-Bromocriptine
-Pergolide
-Ropinirole
· Controlled release Levodopa/Carbidopa
· Amantadine
6.NEUROLEPTIC INDUCED PARKINSONISM
·    Anticholinergic drugs
-Triphexyphenidyl
-Biperiden
-Benztropine
7.DEPRESSION
·    Selegiline
·    Rosagiline
8.INCREASING “ON-TIME” AMONG RESPONSE FLUCTUATIONS
·    Pergolide
·    Entacapone
·    Tolcapone
9.GRAND-MAL SEIZURES
·    Carbamazepine
·    Valproate
·    Add-on-therapy
Lamotrigine
Gabapentin




ON THE BASIS OF CONTRA INDICATIONS

1.PSYCHOTIC ILLNESS
·    Levodopa
·    Dopamine Agonists
-Bromocriptine
-Pergolide
-Ropinirole
·    Anticholinergic drugs
-Diphenhydramine
-Trihexyphenidyl
-Biperiden
2.GLAUCOMA
·    Anticholinergic drugs
-Procyclidine
-Benztropine
-Biperiden
·    Levodopa
3.MELANOMA
·    Levodopa
4.MYOCARDIAL INFARCTION
·    Dopamine Agonists
-Bromocriptine
-Rotigotine
-Ropinirole
5.SEIZURES
·    Amantadine

6.DIFFICULTY IN MICTURITION AND CONSTIPATION
·    Anticholinergic drugs
-Procyclidine
-Trihexyphenidyl
-Diphenhydramine
-Benztropine

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