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Classification of Anti-Psychotic Drugs

Classification of Anti-Psychotic Drugs

Classification of Anti-Psychotic Drugs
On the basis of Chemical Structure:
  1. Phenothiazine Derivatives
· Aliphatic Derivatives e.g. Chlorpromazine
· Piperidine Derivatives e.g. Thioridazine
· Piperazine Derivatives e.g. Fluphenazine
  1. Thioxanthene Derivatives
e.g. Thiothixene
  1. Butyrophenone Derivatives
e.g. Haloperidol
  1. Miscelleneous Structures
· Pimozide
· Molindone
· Loxapine
· Clozapine
· Olanzapine
· Quetiapine
· Risperidone
· Ziprasidone
· Aripiprazole
Class Of DrugDrug’s Name
DibenzoxapineLoxapine / Clozapine
BenzioxazoleRisperidone
DihydroindoloneZiprazidone
DihydrocarbostyrilAripiprazole
ThiobenzodiazepineOlanzapine
DibenzothiazepineQuetiapine
Ø Phenothiazine derivatives:
· Aliphatic compounds
o E.g. Chlorpromazine, Chlorpromazine Hcl, Promazine Hcl
· Piperazine Compounds
o E.g. Prochlorperazine Maleate, Prochlorperazine Mesylate, Triflouperazine Hcl, Perphenazine (Feutazine), Fluphenazine Hcl (Moditen), Fluophenazine Decanoate (Modecate), Fluphenazine Enanthate ( Moditen Enanthate)
· Piperidine compounds
o E.g. Thioridazine Hcl (Melleril), Pericyazine (Newlactil), Pipothiazine (Pipotil), Mesordiazine (Serentil)
· Butyrophenone Derivatives
o E.g. Haloperidol (Serenace), Droperidol (Droleptan), Trifluperidol (Triperidol), Benperidol (Anquil)
· Thioxanthines
o E.g. Chlorprothixene (Taractan), Thiothixene (Narane), Flupenthixol (Depixol), Clopenthixol (Clopixol)
· Ranwolfia Alkaloids
o E.g. Reserpine
· Dihydroindolone Derivatives
o E.g. Molindone (Lidone / Moban)
· Tricyclic dibenzoxazepines
o E.g. Loxapine (Daxolin / Loxapac), Clozapine (Clozaril)
· Diphenyl butyl piperidines
o E.g. Pimozide (Orap), Fluspirilene (Redeptin)
Typical (Neuroleptics)
1. Chemical Classification
· Benzamides
o E.g. Sulpiride
· Butyrophenones
o E.g. Haloperidol, Moperone
· Dibezoxazepines
o E.g. Loxapine, Amoxapine
· Dihydroindolones
o E.g. Molindone
· Diphenylbutylpiperidines
o E.g. Pimozide
· Phenothiazines
Ø Aliphatic
§ E.g. Chloropromazine
Ø Piperidine
§ E.g. Thioridazine, Mesoridazine
Ø Piperazine
§ E.g. Fluphenozine, Perphenazine, Trifluoperazine
· Thiozanthenes
o E.g. Thiothixene, Zuclophenthixol
2. According To Potency
· Low Potency Agents (Dose > 200mg / day)
o E.g. Sulpiride, Chlorpromazine, Thioridazine, Mesoridazine
· Mid To High Potency (Dose 2-120mg / day)
o E.g. Haloperidol, Fluphenazine, Loxapine, Molindone, Trilfluoperazine, Thiothixene Etc.
Atypical (novel Antipsychotic Drugs)
· Dibenzodizepines
o E.g. Clozapine
· Thienobenzodiazepine
o E.g. Olanzapine
· Dibenzothiazepine
o E.g. Quetiapine
· Benzisoxazol
o E.g. Risperidone
· Substituted Benzamides
o E.g. Amisulpride, Remoxipride[1]

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