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Classification Of Ergot Alkaloids

Classification Of Ergot Alkaloids

CLASSIFICATION OF ERGOT ALKALOIDS

A. Natural ergot alkaloids

may be considered as derivatives of lysergic acid.
(a) amine alkaloid - ergometrine (ergonovine) : oxytocic
(b) amino acid alkaloids - ergotamine, ergotoxine (mixture of ergocristine + ergocornine + ergocryptine)

B. Other semisynthetic derivatives
(a)
 dihydroergotamine (DHE), dihydroergotoxine (codergocrine) : antiadrenergic, cerebroactive
(b) 2 -bromo-alpha-ergocryptine (bromocriptine) : dopaminergic
(c) methysergide :anti 5 HT
CHEMICAL CLASSIFICATION of ERGOT ALKALOIDS
Amine Alkaloids:
Ergonovine
Methylergonovine
Methylsergide
Lergotrile
D-Lysergic Diethylamide(LSD)
Amino Acid Alkaloids:
Bromocriptine
Ergotamine
Ergocristine
Ergosine
Ergocomine
Ergocryptine
Hydrogenated Alkaloids:
Dihydroergotamine
Dihydrocristine
Dihydroergosine
Dihydroergocomine

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