Classification of Flouroquinolones (DNA gyrase+topoisomerase)

CLASSIFICATION of Flouroquinolones (DNA gyrase+topoisomerase)

CLASSIFICATION of Flouroquinolones ON THE BASIS OF ANTIBACTERIAL ACTIVIY:

• FIRST GENERATION Flouroquinolones :

Norfloxacin
Nalidixic acid
· SECOND GENERATION Flouroquinolones
Ciprofloxacin
Ofloxacin
· THIRD GENERATION Flouroquinolones
Enoxacin
Lomefloxacin
Levofloxacin
Pefloxacin
· FOURTH GENERATION Flouroquinolones :
Moxifloxacin
Gatifloxacin
Gemifloxacin

THERAPEUTIC CLASSIFICATION of Flouroquinolones

· TREATMENT:
1. Flouroquinolones for  Upper and Lower Respiratory Tract Infections:
Levofloxacin
Gatifloxacin
Gemifloxacin
Moxifloxacin
2. Flouroquinolones  for  TB and atypical myobacterial Infection:
Ciprofloxacin
Levofloxacin
Moxifloxacin
2. Flouroquinolones  for  Gonnococcal Infection:
Ciprofloxacin
Levofloxacin
4. Flouroquinolones  for Anthrax:
Ciprofloxacin
5. Flouroquinolones  for Bacterial Diarrhea:
All quinolones except moxifloxacin
6. Flouroquinolones for Soft tissue,bone,joints and Intra abdominal Infections:
All except norfloxacin
7. Flouroquinolones  for Prostatis:
Norfloxacin
Levofloxacin
8. Flouroquinolones for Skin:
Levofloxacin
· Flouroquinolones  for PROPHYLAXIS
1. Anthrax:
Ciprofloxacin