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CLASSIFICATION OF Sympathoplegics

CLASSIFICATION OF Sympathoplegics

Centrally Acting Agents
Ganglion Blockers
Postganglionic Sympathetic Neuron Blocker
AdrenoceptorBlockers (α and β)
Centrally Acting Agents (stimulates central α2 adrenoceptors)
Methyldopa
Clonidine
Guanabenz
Guanfacine
Ganglion Blockers (nicotinic cholinoceptor agonists)
Trimethaphan
Postganglionic Sympathetic Neuron Blocker
Reserpine
Guanethidine
Guanadrel
AdrenoceptorBlockers (α and β)
Propranolol
Metoprolol
Nadolol, Carteolol, Atenolol, Betaxolol, Bisoprolol.
Pindolol,acebutolol, Penbutolol.
Labetalol, carvedilol
Esmolol. Prazocin
Phentolamine, phenoxybenzamine.
Detailed Classification of Adrenoceptor Blockers

Alpha Blockers
Chemical Classification:
Β-Haloalkylamines: phenoxybenzamine
Substituted Imidazolamines: phentolamine
Phenoxyaxyalkylamines: thymoxamine
Ergot Alkaloids: Ergotamine,Dihydroergotamine
Dibenzapines: Azapetine
Benzodioxans: piperoxan
Indolealkylamines: Yohimbine
Phenothiazines: chlorpromazine
Misc: Prazocin, labetalol
Duration of Action:
Reversible: phentolamine,Prazocin
Irreversibly: phenoxybenzamine
Receptor Selectivity:
Selective postsynaptic α1 blockers: prazocin, doxazosin, terazosin
Predominant postsynaptic α 1 blockers: phenoxybenzamine
Selective presynaptic blockers: tolazoline
Non-selective α 1, α 2 blockers: phentolamine
Therapeutic classification:
Hypertension: prazocin
Benign prostatic hyperplasia: tamsulosin
Raynauds Disease: Phenoxybenzamine, prazocin
Pre-surgical treatment of pheochromocytoma: phentolamine
Glaucoma: phenoxybenzamine
Migraine: ergotamine
Sexual dysfunction: phentolamine, Yohimbine
Beta Blockers
According to receptor selectivity:
Β2 and β1 non selective blockers: propranolol, timolol,nadolol, pindolol
Selective β 1 blockers: metoprolol, acebutolol, esmolol, practalol, betaxolol
Β2 selective blockers: butoxamine
Mixed blockers: labetalol, carvedilol
According to partial agonist activity
Drugs with intrinsic sympathomimetic activity: acebutolol, pindolol,
Drugs without intrinsic sympathomimetic activity: propranolol, metoprolol,atenolol
According to membrane stabilizing or local Anesthetic activity:
Having local anesthetic activity: acebutolol, labetalol, alprenolol,propranolol
Drugs without local anesthetic activity: atenolol, metoprolol, pindolol
Therapeutic Classification:
Hypertension: atenolol, propranolol, metoprolol
Angina Pectoris: nadolol, propranolol
Arrhythmia prohylaxis post Mycocardial Infarction: propranolol, timolol, metoprolol
Migraine: propranolol
Glaucoma: timolol
Heart failure: labetolol, carvedilol
Thyrotoxicosis: propranolol
Supraventricular tachycardia:esmolol with propranolol
Hypertrophic cardiomyopathies: propranolol
Fallots tetrology: propranolol

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