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The simplified biochemistry of Vitamin D metabolism

The very simplified biochemistry of vitamin D metabolism in human body is discussed below

Ultraviolet light when strikes the skin it helps in the formation of Vitamin D3 or cholecalciferol

This to liver where it is converted into 25 hydroxy cholecalciferol

In the Kidneys it is then converted by 1 Alpha hydroxylase into 125 dihydroxycholecalciferol which is also called calcitriol

1 Alpha hydroxylase is inhibited by rising serum calcium levels and it is stimulated by parathyroid hormone and decreased phosphate levels

125 dihydroxycholecalciferol also called calcitriol stimulates absorption of Calcium from intestine kidney and it causes bone resorption

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