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COMMON PAEDIATRIC DRUGS DOSES:


 

The young physician starts life with 20 drugs for each disease, and the old physician ends life with one drug for 20 diseases.

COMMON PAEDIATRIC DRUGS DOSES:
                                  Revision 2017-  M Tauseef Omer


ANTI-PYRETIC,ANALGESC,ANTI-INFLAMATORY..
DRUG
Brand Name
Dose
Indications

Acetaminophen

(paracetamol)
Calpol syrup.
Panadol drops

10mg/kg/dose every 6 hours
Syrup
120mg,160mg/5ml
Tablet/Drops
80mg/ml,
Tab 200,400mg
Antipyretic analgesic

Ibuprofen
Syrup.Brufen
10mg/kg/dose every 6 hours
100mg/5ml
*200mg
*400mg
Antipyretic analgesic

DEXYBRUFIN
DEXY,TERCICA
5mg/kg/dose  every 6 hours
100mg/5ml

Antipyretic
analgesic
Aspirin
disprin
90-130mg/kg/day,6hrly

Tab.300mg
Anti-
inflamatory
Nalbuphine
nalbine
0.1-0.2mg/kg/dose ,6hrly,IV,IM,SC
Inj 10-20/ml


Diclofenac
Dicloran,voltran
>1-3mg/kg/day
Inj 75mg/3ml
Tab 50mg

Morphine

0.15-0.2mg/kg/dose,
IV,IM,SC
Inj 15mg/ml


Pancuronium
Pavulon
60-100mcg/kg then 10-20mcg/kg/dose ,20-60mint
Inj 2mg/ml
Muscles relaxant
Intubation
Only by seniors..
Baclofen
LioresaL,
baclotab
10-15mg/day,8hrly
For 3 days

Muscles relaxant


ANTIEMETICS:
Drug
Brand Name
dose
indications

DIMENHYDRINATE
Inj./syrup.Gravinate
0.5mg/kg/dose every 6 hours
12mg/5ml

Antiemetic
Metoclopramide
Inj./syrup maxolon.
Inj.metomide
0.2-0.5mg/kg/day every 6 hours
5mg/5ml
10mg
Antiemetic

Can Cause sever Dystonic Reactions
Not Recommended  in paeds anymore.

Domperidone
Syrup.Peridone.
Syrup Domel
Inj.motilium
0.5mg/kg/dose every 6 hours
5mg/5ml
10mg
Antiemetic

Can cause severe dystonic reactions

Not Recommended  in paeds anymore.
ONDANSETRON
Inj.tab Onset
0.15mg/kg/dose
2mg/ml
2,and 4mg
Chemoth-vomiting
                                                                   ANTIBIOTICS
QUINOLONES:
drug
Brand Name
Dose
strength
indications
Ciprofloxacin
Syrup.novidat
Tab.novidat.
Syrup.Gavel.
Syrup.Mytel
ORAL:20-30mg/kg/day every 8-12hrs.
I/V:4-15mg/kg/day every 8-12hourz
*125mg/5ml
*250mg/5ml
Tab.100mg
,250mg and
,500mg

Typhoid.
UTI’S.
Nalidixic Acid
Susp.negram.
Tab.negram
55mg/kg/day every 6 hourly
250mg/5ml
500mg

Lower UTI’s
CEPHALOSPORINS
Drug
Brand Name
Dose
indications

1st Generation




Cephalexin
Ceporex
25-100mg/kg/day every 6 hrz.
*125mg/5ml
*250mg/5ml
Drops:125mg/ml

Cephradine
Syp.velosef
50-100mg/kg/day every 6 hrz
*125mg/5ml.
*250mg/5ml
250mg/vial.
500mg/vial.

2nd generations






Cefaclor
Syp.ceclor
20-40mg/kg/day every 8 hrly
125mg/5ml.
250mg/5ml.
DROPS:125mg/ml.

Cefuroxime
Inj.zinacef
Syp zecef
50-100mg/lg/day every 8hrly.
125mg/5ml,
250mg/5ml
250mg/vial.
750mg/vial.

3rd generations





Ceftriaxone
Inj.Rocephin.
Inj.oxidil.
Inj.dayline.
Inj.pathocef.
Inj.titan
50-75 mg/kg/day every 12 hrly.
Meningitis:100mg/kg/day every 12hrly.

250mg/vial.
500mg/vial.
1g/vial.
Liver toxity
Cefotaxime
Inj.claforan.
Inj,Yarker.
100-200mg/kg/day  every 12hrly

250mg/vial
500mg/vial.1g/vial.
Renal toxicity
Ceftazidime
Inj fortum
100-200mg/kg/day.8hrly


Anti pseudomonas
CEFIXIME
SYP.cefspan.
Syp.caricef.
Syp.cefiget.
Syp.synocef.
Syp.cef-od
Syp.cefim.
10mg/kg/day in 12hrz.or 24hrz.
100mg/5ml.
SD.200mg/5ml


Amoxicillin
Syp.Amoxil.
Syp.suprmax
20-40mg/kg/day every 8-12hrz.
125mg/5ml.
250mg/5ml
Cap.250mg and 500mg

Amoxicillin-clavulanate
Syp/inj.
Augmentin,
Calamox
20-45mg/kg/day every 8-12hrs.
80-90mg/kg/day for otitis media.
156mg/5ml.
DS syrup 312mg/5ml
457mg/5ml
Tab 357mg,625mg,
and 1gm

AMPICILLIN
Syp.inj Penbritin

100-300mg/kg/day every 8 hrly
125mg/5ml 
250mg/5ml 
125mg/5ml
.250mg/5ml
Gram positive..
Metronidazole
Tab.,Syrup,Inj.Flagyl
35-50mg/kg/day every 8hrly
Syr.200mg/5ml
Tab 200mg,400mg

Meropenem
Inj.meronem
60-120mg/kg/day,every 8hrly
(as infusion in 20 c.c Normal Saline over 30 minutes)
500mg and 1Gm


Vancomycin
Inj.vanco
40-60mg/kg/day, every 8hrly
(as infusion in 20 c.c Normal saline over 45 minutes)
> Much slower than Meropenem.
Inj:500mg/vial,1g/vial.

Staph and resistan gram positive infections
AMIKACIN
Inj.gracil
7.5-10mg/kg, 8 hrly
25mg/ml,
250mg/ml









Tazobactem+Piperacillin
Tanzo
150-300mg/kg/day,8hrly
2gm pipercacillin


Nosocomial pneumonia
PENCILLIN-G
Inj.Benzyl-pencillin
1-4 lac/kg/day,6hrly
     5-10 lac
    units/vial
Don’t Forget
Test Dose
Streptococcal infections
Benzathine Penicillin
Penidure LA,
INJ Benzibiotic
6/12 lac  unit IM,3WEEKLY
Inj 6/12 lac

Don’t Forget
Test Dose
Rheumatic fever prophylaxis
Clarithromycin
Susp Klaricid,pathocin,
7.5-15mg/kg/day,12hrly
(if i/v,, then as infusion over 30 min)
125mg/5ml
Tab.500mg
IV INFUSION IN SALINE OVER 4 HR
Azithromycin
Syp Azit,zeenase
10mg/kg,OD,3days
200mg/5ml


Artemether
Artem
3.2mg/kg IM state,then 1.6mg/kg ,OD,4days
Inj 40mg.
Cap.80mg

malaria
Atrtemther+lumefantrine
Comether,

arceva
3mg/kg/day
Syp.15mg artemether/5ml
(15/90)
(30/180)
Tab 40/240
Tab 80/480


Quinine sulfate

IV 10mg/kg loading over4 hr then same as 8hrly
Oral..double dose

Cerebral malaria.
Chloroquine
nivaquine
10mg/kg stat then 5mg/kg aftr 6 hr then 5mg/kg OD for 2days.

50mg/5ml
TaB 150MG
Prophylaxis,5mg/kg,once weekly.


ANTITUBERCULOUS

Give before breakfast.




ISONIAZID
ISONEX
10mg/kg/day,OD
Syp50mg/5ml
Tab.100mg
Prophylaxis5-10mg/kg/day OD
RIFAMPICIN
Rimactane,rifdin
15mg//kg/day OD,1/2HR b4 Breakfast
Syp.100mg/5ml
Tab.300, 450mg
Nesseria carrier..10-20/kg/day OD,4days
PYRAZINAMIDE

30mg/kg/day,OD
Syp.250mg/5ml
500mg

ETHAMBUTOL
myambutol
25mg/kg/day OD
>5year

40Omg

STREPTOMYCIN
-
20-40mg/kg/day,OD,IM
Inj 1G


Myrin
Rifampicin/
INH/
Ethambutol
150/
75/
300








Myrin-P

Rifampicin/
INH/
Ethambutol/
Pyrazinamide

150/
75/
275
400

Other Dosage available as :

120/
60/
225/
300



Trimethprim+sulfamethoxazole
septran
8-10mg/kg/day,12hrly
UTI prophylaxis 2mg/kg ,OD
Syp TMP 40mg
Tab 100mg\
DS..200mg
PCP..10-20mg/kg/day
UTI,BOILS


ANTIVIRAL



ACYCLOVIR
Zovirax,aclova
Acylex
20 mg /kg/dose (give 8 hourly)

as infusion over 60 minutes
Syp 200mg/5ml
Inj 250mg
Herpes simplex and varicella zoster
Encephalitis

(The dosage for skin lesion is 10mg/kg/dose given 8 hourly)


ANTIHELMINTHIC



MEBENDAZOLE
Vermox
Vermol

100mg,12hrly,3days
>2yr children
Syp 100mg/5ml
Tab 100 mg
Tab 500 mg
antihelminthics
Albendazole
zentel
200mg,single dose
 >2 yr children
100mg/5ml
Tab.200mg
antihelmintjics
Levamisol
ketrax
2.5mg/kg ,single dose
40mg/5ml

antihelminthics


    
INOTROPIC  AGENTS
DOPAMINE
Inj.Inotropin
5-15mcg/kg/min or
0.012*dose*weight
      200mg/5ml

DOBUTAMINE
Inj.Dobutrex
10-20mcg/kg/min
0.01*dose*weight

(These formulae are for Dobutrex250mg/5ml
Dopamine 200mg/5ml
- Do check the strength of your injections before you advise on t/m ticket)
      250mg/5ml


The Above two Inotropes, Dobutamine and Dopamine are given as a continuous infusion for whole 24 hours. Never stopped even if the patient is being transported or being given a blood transfusion or undergoing any procedure.
If  these two drugs do not give response , then Infusion of  NorEpinephrine (0.1 micro gram /Kg/min is started along with these)

DIGOXIN
LANOXIN
IV Digitilizing dose 0.10-0.30mg/kg divided in fractions ot PO 0.04mg/kg divided ib fractions as
Give half dose of total dose stat.
Then1/4th 8hr later,
Then1/4th 16hr later
Thengive 1/4th as maintenance dose after 24 hr IV OR PO..


OR maintence 0.1-0.015mg/kg/day 12hry
Adrenaline
1:10000 sol..used
(made by dilution)
0,1ml/kg/dose IV 5mint upto 0.5ml/kg

Inj 1:1000,
1ml/1mg
1mg is 1000 Units

Atropine

0.02mg/kg/dose

Sinus bradycardia and organophosphorus


ANTIHYPERTENSION


Propranolol
inderal
0.5-1mg/kg/day6-12hrly

TOF..0.15-0.25mg/kg/dose slow IV repeat after 15 mint.
PO2mg/kg/day,6Hrly

Nifedipine
Adalate
0.25-0.5mg/kg/dose PO,SL,6hrly
Tab.20mg
Cap.10mg
Methyledopa
aldomate
10mg/kg/day,6-12hrly upto65mg/kg/day
Inj50mg/ml,tab.250,500mg

Captopril
Capoten,capase
0.5-0.6mg/kg/dose,6hrly
Upto 6mg/kg/day

Tab12.5mg,25mg
Sodium Nitropruside
Nipride
0.25-6ug/kg/min


Diaxoxide
Hyperstat
IV 3-5mg/kg repeat aftr 15 mint
15mg/ml

Hydralazine
aspresoline
0.15mg/kg/dose IV,
Repeat 90 mint




ASTHMA


Salbutamol
Ventoline
Oral0.2-0.4mg/kg/day,8hrly
Syp.2mg/5cc,sol.5mg/ml,
Nebulization
0.1-0.2mg/kg/dose
Aminophyline

5mg/kg IV ovr 20 mint.
Inj 250mg/10cc



Inhaler


Beclomethasone
becotide
50-100mcg,2-4 times a day,MAX 10 puff daily
50ug/puff

Salbutamol
ventoline
2 puff,2-4 times aday
100 ug/puff

Fluticasone
flunisolide
4 puff aday




Nebulization


Salbutamol
Resp. solution
<1 yr  0.1mg/kg/dose in 1.5cc Normal Saline  (nebulize 4 to 6 hourly)
1-5 Yr  2.5mg/dose made in NS (nebulize 4 to 6 hrly)
>12 yr 2.5  to  5 mg /dose (nebulize 4 to 8 hrly)
Comes in variable strength in our ICU.
usually,
5mg/1cc solution
May take it with syringe
Ref. Harriet Lane 20th Ed
Ipratropium
Atrovent2%
<12 yr  0.25 mg /dose repeat after 20min, then 2-4 hrly as needed.

>12 yr 0.5mg /dose repeat after 30 min, the 2 to 4 hrly as needed
Comes in variable strength in our icu,
Usually,

0.25mg/ml
Ref. Harriet Lane 20th Ed
Beclomethasone
Clenil Aerosol
0.04 mg nebulized X B.D

Check strength on Vial that is available in ICU and dilute in 2cc Normal Saline.







Ref. Harriet Lane 20th Ed
Epinephrine

Croup: (0.5mL/Kg of 1:1000 solution diluted in 3ml Normal Saline )(with maximum dose as :
4Year or less > 2.5ml/dose
More than 4 yr 5ml/dose


Post Endotracheal Extubation :
0.1 ml / kg of 1:1000 in 1.5 cc normal Saline

Ref. Harriet Lane 20th Ed


ANTICOAGULANTS


Heparin

50unit/kg IV bolus,then infusion 10-25/kg/hr

Adjust according to APTT
Warfarin

0.1mg/kg/day PO,

Maintence 0.05-0.34mg/kgday,6hrly
Adjust according to PT



DIURETCS


Mannitol 20%

Diuretic.0.25mg/kg/dose in 30
After checking B.P
20gm/100ml
Cerebral edema.initial 0.5-1gm/kg/dose then.0.25-0.5mg/kg/dose
Acetazolamide
Diamox 250 mg tab
Diuretic (30 mg/kg/day)
divided 8H or 6 H


Frusemide
lasix
1-2mg/kg/dose,BD,TDS upto 6mg/kg.dose,
Inj1ml/10mg,tab20,40mg

Spironolactone
aldactone
1-3mg/kg/day,12hrly
25/100mg

Naloxone

0.01-0.2mg/kg/dose,at 3mint interval
0.04mg/ml
Morphine poisoning


ANTICONVULSANTS/SEDATIVES:
DIAZEPAM
Inj.Valium
0.1-0.5mg/kg/dose.

If given i/v, give slowly over 60 seconds
Inj.10mg/2ml vial,
Tab.2mg,5mg,10mg.
Fits/epilepsy
PHENOBARBITONE
Debritone,pheno
Loading:20mg/kg stat,
Mainten.:4-8mg/kg/day every 12-24 hrs
Tab.30mg
Syp.20mg/5ml
Inj 200mg
Fits/epilepsy
MIDAZOLAM
Inj.Dormicum
0.1mg/kg/dose,every 5mint upto 5 time..max 0.6mg/kg

If given i/v, give slowly over 60 seconds
5mg/5ml

Start with Infusion 0.1-0.2ug/kg/min

To get response , may increase to 18ug/kg/min
PHENYTOIN
DILANTIN

Syp epitoin
Load with inj phenytoin 20mg/kg/dose in 20c.c normal saline over 20min.
then;
5-10mg/kg/day,BD
Syp 125mg/5ml
epilepsy
CLONAZEPAM
RIVOTRIL
0.01-0.03mg/kg/day,8hrly,increase 0,5mg/day for 3days upto 0.3mg/kg/day
Drops2.5mg/ml ??

tab 0.5 mg
tab  2mg



epilepsy
Sodium valproate
Epival,epilim
10mg/kg/day,12hrly,increase5mg/kg/week upto 60mg/kg/day

(hepatic side effects)
250mg/5ml

Tab 250mg
Tab 500mg
epilepsy
Levetiracetam
Lerace
Klevra
Levitra
10 mg/kg/dose X 12H
May increase to max 30mg/kg/dose X 12… increase 2 Weekly if tolerated .
(Renal Side effects)
100mg/ml drops

Tab 250mg
tab 500mg
Tab 750 mg

LAMOTRIGINE
lamictal
2mg/kg/day,12hrly for 2week then 5hen 5mg/kg/day
Tab25,50,100mg
Adjuvant epilepsy
TOPIRAMATE
TOPAMAX
>2yr ..25mg at nite..then increase 1-3 weeks by  1-3mg/kg/day upto5mg/kg/day
Tab.25,50mg
Adjuvant epilepsy
CHLORAL HYDRATE

For Sedation : 8mg/kg/dose

250mg/5ml  ??
sedative

ANTIALLERGIC
AND STEROIDS


Chlorpheniramine
Tab/Syp.Avil.

1-2mg/kg/day every 6 hrz.or
1TSF for 10kg.
<10kg ½ TSF.
>10kg 2TSF.
15mg/5ml

tab 25mg
tab 50mg
tab 75 mg
22.7mg/2ml
Loratidine
Syp.Antial,lorel
0.2-0.3mg/kg/dose,OD
5mg/5ml
Tab 10mg

Cetrizine
Rigix,zyrtec
0.2-0.3mg/kg/dose,OD
5mg/5ml
10mg
Diphenhydramine
benadryl
4-6mg/kg/day,6hrly IV,PO
13.5mg/5ml

Hydrocortisone
Inj.Solucortef
Septic shock:35-50mg/kg/d,4-6hrly

Acute asthma 5mg/kg/dose stat,1-2mg/kg/day 6hrly

100mg/2ml.
250mg/2ml.
500mg/4ml


Stress dose Hydrocortison in CAH:
if mild stress(like URTI/AWD/etc), increase dose to 3 times.

if comes in crisis/obtunded, then,
100mg/m2 per day

Must get Endocrinology consult.
Dexamethasone
decadron
Anti-inf..0.3mg/kg/day,6-12hrly,
Meningitis..0.6mg/kg/day,6hrly for 4 days
Cerebral edema..loading 1-2mg/kg/dose once then 0.2-0.5mg/ kg/day,6hrly
Before Extubation..
0.25mg-0.5mg/kg/day,8hrly










4mg/ml..


Tab 0.5mg
Prednisolone
Deltacortil











Syp Steron (15mg/5ml)

Asthma and asthma 1-2mg/kg/day, PO,
Nephrotic Syndrome: Stat with 60mg/m2 /Day

Formula to Calculate Surface area from weight (x)  is :

S.A = (4x + 7) / (90 + x)
       = _____ m2



Tab Deltacortil
            (Tab 5mg)

Syp Steron         
           (15mg/5ml)

Syp Neupred



Methyl Prednisolone acetate

(Depo-Medrol)


Methyl Predniolone Sodium Succinate

(Solumedrol)


Acute asthma..2mg/kg/dose,6hrly.
Acute spinal cord injury
30mg/kg in 15 mint folowed by 5mg/kg/hr for 23 hr.


Also indicated in :
Sensitivity
Transplantation
Cerebral Edema
UC
crohns
Aspirationpneumonia
SJS
rheumatoid arthritis
Osteoarthritis
Dermatoses
Hay Fever
Collagen Disorders

Inj 40mg,125mg,500mg

Tab 2,4,,8,16,32 mg


NEWER ADDITIONS
Fluconazole

Load with 12mg/kg/dose,
then 6mg/kg/day(24 hours after loading dose)
Antifungal
Both syrup and Iv forms available.

Syp Diflucan(50mg/5ml)

Syp Fzole

Ursodeoxycolic Acid
Neonate:
10mg/kg/day (OD dose)

Child:
20 mg /kg/day (divided BD)
Advised in cholestatic jaundice

Syp Urso
(250mg/5ml)
Rifaxamine

10mg / kg /dose (OD) per NG
Advised in Hepatic failure to clear GUT off ammonia producing bacteria.

Tab Rifaxa 200mg

Tab Nixaf 550mg

Tab Xifaxa 550mg
Sodium benzoate

1ml per Kg per NG
Advised in hepatic failure to bind free ammonia in GIT

May be acquired from Children Hospital Lahore’s Pharmacy
Nitazoxanide (100mg/5ml)

1-3 year: 100mg PO BD for 3 days

4-11 year: 200mg PO BD for days

>12 years  500mg PO BD for 3 days
Advised in chronic giardiasis

Syp NT-TOX (100mg/5ml)

Tab NT-TOX 500mg

Syp Atizox(100mg/5ml)

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