Detailed histology Of HEPATOCYTES
The hepatocytes are polyhedral (5-12 sides) in shape (80% of cell population) with mostly single rounded nucleus. 25% of hepatocytes are binucleated. Each nucleus contains prominent nucleolus.
The plasma membrane of hepatocytes bear microvilli more numerous towards sinusoids than towards bile canaliculus). The cytoplasm of hepatocytes is acidophilic due to richness in smooth endoplasmic reticulum and glycogen but contains basophilic bodies as well due to RER.
The hepatocytes are arranged in radiating plates of one to two cell thicknesses around the central vein. These cords or plates of hepatocytes branch and anastomose with other cords and in this way form a three dimensional framework of liver parenchyma.
The hepatic plates are separated from each other by blood sinusoids and by perisinusoidal tissue spaces (spaces of Dlsse). The sinusoids are lined by two types of cells; the simple squamous endothelial cells (non-continuous epithelium) and von Kupffer cells (stellate shaped phagocytic cells of reticuloendothelial system or mononuclear phagocytic or macrophage system). The plasma escaping from sinusoids passes out into the perisinusoidal space, which surrounds the sinusoids.
So perisinusoidal space is present between the hepatic sinusoids and hepatocytes. This space contains reticular fibres, stellate-shaped adipocytes (lipocytes or Ito cells), plasma (tissue fluid) and microvilli of hepatocytes. Ito cells are typical stellate shaped cells. Space of Disse continues into space of MalL, which contains structures of portal triad. The lymphatic vessels also begin in the spaces of Mall along with other structures of portal triad. The liver produces 50% of the lymph found in the thoracic duct.
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