Follicles in a normal thyroid gland contain colloid that is involved in thyroid hormones synthesis. In states of continuous/chronic low thyroid hormones in body , the thyroid follicles undergo hyperplastic changes in response to high TSH levels. Later, a stage comes when all the demands of body for thyroid hormones are met and then the gland goes to Colloid/Non Toxic form, where the follicular epithelium may be involuted but the follicles almost always contain rich Colloid , as shown in the slides. Please do not confuse Multinodular goiter with colloid goiter. That is a different thyroid pathology. But do remember, that Colloid Goiter is non-toxic.
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