What is Immunologic Tolerance ?

 

What is Immunologic Tolerance ?

Immunologic tolerance is a state in which the individual is incapable of developing an immune response to a specific antigen

Self tolerance refers to lack of responsiveness to an individual’s antigens

In this way it underlies our ability to live in harmony with our own cells and tissues

 

What is the mechanism of immunologic tolerance ?

1-Central tolerance

Peripheral tolerance

–Clonal deletion by activation induced cell death

–Clonal anergy

–Peripheral suppression by T cells