Classification of Anti-Malarials (Classification of Anti-malarial drugs)(Pharmacologocal Classification of Antimalaria Drugs)

CLassification of AntiMalaria Drugs

Drugs used in Malaria are classified as follows:

 Chemical Classification AntiMalaria Drugs

1) 4-Aminoquinolone used in malaria
Choroquine
Amodiaquine
2) 8-Aminoquinoline used in malaria
Primaquine
3) Quinoline methanol used in malaria
Quinine
Quinidine
Mefloquine
4) Folate antagonist combination used in malaria
Sulfadoxine-pyrimethmine (fansidar)
Chlorproguanil-dopsone
Pyrimethamine + Dapsone (Maloprin)
5) Antibiotics
Dexycycline
Clindamycin
Spiramycin
6) Phenanthrene methanol used in malaria
Halofantrine
7) Aryl alcohol used in malaria
Lumefantrine
8) Sesquiterpene lactone endoperoxide used in malaria
Artemisinins

AntiMalaria Drugs According To Target Stage

1) Blood Shizonticide used in malaria
Chloroquine
Quinine
Mefloquine (for P.falciparum & P.vivax only)
Pyrimethamine
Proguanil
Tetracycline
Doxycycline
Clindamycxin
Halofantrine HCl
Artemisinin
2) Tissue Schizonticide used in malaria
Primaquine (for P.vivax & P.ovale only)
3) Gametocides used in malaria
Chloroquine (not against gametocytes of P.falciparum)
Pyrimethamine
Quinine (not against gametocytes of P.falciparum)
Primaquine (for P.falciparum)

For Treatment of
1) Drugs of Sensitive P.falciparum infections
Chloroquine
2) Drugs of  Non-faciparum infections
Chloroquine
3) Drugs of  Uncomplicated infections with chloroquine resistant P.falciparum
Quinine
Doxycycline
Clindamycin
Fansidar
Malarone
Mefloquine
Artesunate or artemether
Coartem
4) Drugs of  Severe or complicated infections with P.falciform
Quinidine
Artesunate
Artemether

 Chemoprophylactics used in MALARIA
Ø Drugs for Areas without resistant P.falciparum : Chloroquine
Ø Drugs for  Areas with multidrug resistant P.falciparum : Malarone,Doxycycline
Ø Drugs for  Areas with chloroquine resistant P.falciparum : Mefloquine,Artemisinins,Halofantrine
Ø Drugs for  Terminal prophylaxis of P.vivax and P.ovale: Primaquine
Other Tharapeutic Use
1) Drugs for  Amoebic liver abcess
Chloroquine
2) Drugs for  Babesiosis
Quinine
Clindamycin
3) Drugs for  Pneumocystis Jirveci infection
Clindamycin + Primaquine
Atovaquone
4) Drugs for  Toxoplasmosis
Pyrimethmine
Clindamycin
4) Drugs for  Autoimmune disorders
Chloroquine
Hydrochloroquine

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