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Classification of Anti-Parkinsonism Drugs(Drugs used in Parkinsons Disease)(Pharmacological Classification Of Anti-Parkinsonism Drugs)

CLASSIFICATION OF Anti-Parkinsonism Drugs
Anti-Parkinsonism Drugs(Drugs used in Parkinsonism) are classified as follows :
CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF CHEMICAL PROPERTIES:

1.AMINO ACID PRECURSOR OF DOPAMINE used in Parkinson’s Disease
·    Levodopa
2.ANTIVIRALS used in Parkinson’s Disease
·    Amantadine
3.ERGOT DERIVATIVES used in Parkinson’s Disease
·    Bromocriptine
·    Lysuride
·    Pergolide
·    Carbergoline
·    Quinagolide
·    Mesulergine
4.MORPHINE DERIVATIVES used in Parkinson’s Disease
·    Apomorphine
5.NON ERGOT DERIVATIVES used in Parkinson’s Disease·  
    Pramipexole
·    Ropinirole
·    Rotigotine
6.ENZYME INHIBITORS used in Parkinson’s Disease
·    Selegiline (MAO-B inhibitor)
·    Carbidopa (Dopamine Decarboxylase inhibitor)
·    Benserazide (Dopamine Decarboxylase inhibitor)
7.PLACEBO used in Parkinson’s Disease
·    IPX066

8.FATTY ACID used in Parkinson’s Disease
·    Omega 3
Omega 3 in diet protects brain cells by preventing misfolding of a protein resulting from a gene mutation in neurodegenerative diseases like Parkinson’s and Huntington’s.


CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF MECHANISM OF ACTION

1.DRUGS causing SYNTHESIS OF DOPAMINE
·    Levodopa
2.DRUGS causing STIMULATION OF DOPAMINE RECEPTORS
·    Bromocriptine
·    Lysuride
·    Pergolide
·    Carbergoline
·    Quinagolide
·    Apomorphine
·    Rotigotine
·    Ropinirole
·    Pramipexole
3.Drugs Causing RELEASE OF DOPAMINE FROM INTACT DOPAMINERGIC TERMINALS
·    Amantadine
4.Drugs BLOCKING EXCITATORY CHOLINERGIC ACTIVITY
ANTICHOLINERGICS
·    Diphenhydramine
·    Trihexyphenidyl
·    Benztropine
·    Biperiden
·    Procyclidine
·    Orphenadrine
ANTICHOLINERGICS/ANTISPASMODICS
·    Scopolamine
·    Dicyclomine
5.Drugs RETARDING BREAKDOWN OF DOPAMINE
·    Selegiline
·    Rosagiline
·    Tranylcyproxime
·    Phenelzine
·    Isocarboxazid
6.Drugs PREVENTING METHYLATION OF LEVODOPA
·    Entacapone
·    Tolcapone
7.Drugs PREVENTING BREAKDOWN OF LEVODOPA IN THE PERIPHERAL TISSUES
·    Carbidopa
·    Benserazide
8.Drugs DELAYING RE-UPTAKE OF DOPAMINE
·    Amantadine


CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF THE DOPAMINE RECEPTORS EFFECTED

1.D2 Receptor Drugs
·    Bromocriptine
·    Lysuride
·    Carbergoline
·    Quinagolide
·    Ropinirole
2.D1 AND D2 Receptor Drugs
·    Pergolide
·    Apomorphine
3.D3 Receptor Drugs
·    Pramipexole


CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF SITE OF ACTION

1.CENTRALLy acting ANTI-PARKINSONISM DRUGS  
·    Levodopa
·    Selegiline
·    Apomorphine
·    Trihexyphenidyl
2.PERIPHERALLY ANTI-PARKINSONISM DRUGS 
·    Carbidopa
·    Entacapone
3.CENTRALLY AND PERIPHERALLY ANTI-PARKINSONISM DRUGS 
·    Amantadine
·    Bromocriptine
·    Tolcapone


CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF ROUTE OF ADMINISTRATION
1.ORALLY Administered Anti-Parkinsonism Drugs
·    Levodopa
·    Carbidopa
·    Amantadine
·    Bromocriptine
·    Trihexyphenidyl
·    Selegiline
·    Procyclidine
·    Orphenadrine
2.SUBCUTANEOUS INJECTION Anti-Parkinsonism Drugs
·    Apomorphine
·    Apomorphine accompanied by anti emetic e.g. Domperidone
3.ORAL+INJECTION Administered Anti-Parkinsonism Drugs
·    Benztropine
·    Biperiden
·    Diphenhydramine

CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF THERAPEUTIC USES

1.Drugs for RIGIDITY in Parkinson’s Disease
·    Levodopa
·    Carbidopa
·    Anticholinergic drugs
-Diphenhydramine
-Benztropine
-Procyclidine
2.Drugs for BRADYKINESIA in Parkinson’s Disease
·    Carbidopa
·    Levodopa
·    Benserazide
·    Co-reldopa(Levodopa+Carbidopa)
·    Co-beneldopa(Levodopa+Benserazide)
3.Drugs for TREMORS in Parkinson’s Disease
·    Diphenhydramine
·    Orphenadrine
·    Biperiden
·    Benztropine
·    Amantadine
4.Drugs END-OF-DOSE AKINESIA in Parkinson’s Disease
·    Bromocriptine
·    Selegiline
·    Levodopa+Selegiline
·    Rosagiline

5.Drugs for ON-OFF PHENOMENON in Parkinson’s Disease
·    Dopamine Agonists
-Bromocriptine
-Pergolide
-Ropinirole
· Controlled release Levodopa/Carbidopa
· Amantadine
6.Drugs for NEUROLEPTIC INDUCED PARKINSONISM
·    Anticholinergic drugs
-Triphexyphenidyl
-Biperiden
-Benztropine
7.Drugs for DEPRESSION in Parkinsonism
·    Selegiline
·    Rosagiline
8.Drugs INCREASING “ON-TIME” AMONG RESPONSE FLUCTUATIONS in Parkinsonism
·    Pergolide
·    Entacapone
·    Tolcapone
9.Drugs for GRAND-MAL SEIZURES in Parkinsonism
·    Carbamazepine
·    Valproate
·    Add-on-therapy
Lamotrigine
Gabapentin






CLASSIFICATION OF ANTI-PARKINSONISM DRUGS ON THE BASIS OF CONTRA INDICATIONS

1.Drugs contra-indicated in PSYCHOTIC ILLNESS
·    Levodopa
·    Dopamine Agonists
-Bromocriptine
-Pergolide
-Ropinirole
·    Anticholinergic drugs
-Diphenhydramine
-Trihexyphenidyl
-Biperiden
2.Drugs contra indicated in GLAUCOMA
·    Anticholinergic drugs
-Procyclidine
-Benztropine
-Biperiden
·    Levodopa
3.Drugs contra indicated in MELANOMA
·    Levodopa
4.Drugs contra indicated in MYOCARDIAL INFARCTION
·    Dopamine Agonists
-Bromocriptine
-Rotigotine
-Ropinirole
5.Drugs contra indicated in SEIZURES
·    Amantadine

6.Drugs contra indicated in DIFFICULTY IN MICTURITION AND CONSTIPATION
·    Anticholinergic drugs
-Procyclidine
-Trihexyphenidyl
-Diphenhydramine
-Benztropine

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